Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment
نویسندگان
چکیده
منابع مشابه
Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment.
Influenza A virus (IAV) has a segmented genome that allows for the exchange of genome segments between different strains. This reassortment accelerates evolution by breaking linkage, helping IAV cross species barriers to potentially create highly virulent strains. Challenges associated with monitoring the process of reassortment in molecular detail have limited our understanding of its evolutio...
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Reassortment is fundamental to the evolution of influenza viruses and plays a key role in the generation of epidemiologically significant strains. Previous studies indicate that reassortment is restricted by segment mismatch, arising from functional incompatibilities among components of two viruses. Additional factors that dictate the efficiency of reassortment remain poorly characterized. Thus...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2015
ISSN: 1537-1719,0737-4038
DOI: 10.1093/molbev/msv044